WASHINGTON (Sept. 22, 2025)—Trump Administration Federal health officials are preparing new guidance on the use of acetaminophen, commonly sold as Tylenol, during pregnancy amid concerns that it may be associated with a higher risk of autism in children. While acetaminophen remains the most frequently recommended pain and fever reliever for pregnant women, researchers are urging caution as studies continue.
Autism Prevalence and Public Health Concern
Trump Administration officials said the initiative stems from the rising prevalence of autism diagnoses in the United States. Earlier this year, the Centers for Disease Control and Prevention reported that one in 31 American 8-year-olds was diagnosed with autism in 2022, up sharply from one in 150 in 2000.
Trump previewed the move Friday, telling reporters, “Autism is totally out of control. I think we, maybe, have a reason why.”
Kennedy has made the search for autism’s causes a centerpiece of his health agenda. While many public health experts attribute the rise to broader diagnostic criteria and increased awareness, Kennedy argues that environmental factors, including chemical exposures, could be contributing.
Autism is a spectrum condition that can affect social communication, behavior, and language development. Symptoms range from mild to severe.
Scientific Debate Over Acetaminophen Safety
Evidence linking acetaminophen use in pregnancy to autism remains limited and inconclusive. Most studies are observational, meaning they can identify associations but not prove causation.
A review published last month in BMC Environmental Health examined existing research and suggested that acetaminophen exposure in pregnancy may be associated with neurodevelopmental effects, including autism. The authors recommended “judicious use,” emphasizing the lowest effective dose for the shortest duration under medical supervision. However, the review stopped short of advising against acetaminophen altogether.
Major medical groups continue to recommend its use when necessary. The American College of Obstetricians and Gynecologists states there is “no clear evidence” that responsible acetaminophen use causes developmental issues and warns against leaving maternal pain or fever untreated, as both may pose risks to the fetus.
Manufacturer and Expert Responses
Kenvue, the maker of Tylenol, strongly disputes any link between acetaminophen and autism. In a statement, the company said: “Over a decade of rigorous research, endorsed by leading medical professionals and regulators, confirms there is no credible evidence connecting acetaminophen to autism.”
Independent experts have echoed caution. Many researchers stress that further peer-reviewed studies are needed before drawing firm conclusions. Ongoing projects at the National Institutes of Health and other institutions aim to explore potential connections more thoroughly, though results may take years.
For now, health professionals advise pregnant women to discuss all medications with their doctors, weigh risks and benefits, and follow established medical guidance.
